An experimental drug that has led to the successful regrowth of permanently lost teeth in mice and ferrets is to be tested in human trials. The intravenous treatment suppresses activation of the uterine sensitization-associated gene-1 (USAG-1) protein, which inhibits tooth growth. Experiments on animals had no apparent ill side effects. Scientists will test the drug on 30 human males between the ages of 30 to 64 from September 2024 through August 2025. "We want to do something to help those who are suffering from tooth loss or absence," lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano University Hospital in Japan, said. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."
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